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On Thursday, federal researchers gave up on their plans to
carry out the large scale experimental testing of an AIDS vaccine the National Institutes of Health
had developed. A similar attempt was recorded last September from drug maker
Merck & Co.; the results however were not as good as company officials
expected: several volunteers were left with increased vulnerability to HIV
infection.
Dr.
Anthony Fauci, director of the National Institute of Allergy and Infectious
Diseases, took full responsibility for the decision, adding however that it
took several months of debates to reach this resolution.
Once
the results of the Merck vaccine were out, Anthony Fauci initially delayed his
project and then scaled down the sum of $160 million that was
supposed to go into the testing of his NIH vaccine. As PAVE, the Partnership
for AIDS Vaccine Evaluation, had a very similar approach to that attempted by
Merck, government researchers have been trying to figure out the reasons for
its failure, in order to perfect their own product.
The Merck vaccine was the first and most promising out of a
newly-developed class of HIV vaccines that had been approved for human testing.
It was developed from a version of the common cold virus (adenovirus type 5),
which helped with the delivery of three synthetically produced genes (gag, pol
and nef) of the AIDS virus.
Dr. Alan Bernstein, Global HIV Vaccine Enterprise executive
director, fully supports Dr. Fauci’s decision and considers that currently,
there is an "urgent need for a diversity of new approaches to H.I.V.
vaccine design."
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