In a post on its newly opened blog, Too, Sergey Brin, one of the two
co-founders of Google, has decided to speak about a sensitive issue: he carries
a specific gene mutation that increases his likelihood of contracting
Parkinson’s disease.
Sergey Brin has discovered through 23andMe, the genetics
testing start-up co-founded by his wife, Anne Wojcicki, that he carries a
particular mutation of the LRRK2, the gene responsible for Parkinson’s. The
mutation, known as G2019S, is rare even among people with the disease, but in
some ethnic groups, accounts for a substantial proportion of familial
Parkinson's.
Based on these findings, Sergey Brin said that he has higher
chance of developing Parkinson's in his lifetime than the average person.
“In fact, it is somewhere between 20% to 80% depending on
the study and how you measure,” he wrote.
Brin’s mother, who already has been diagnosed with Parkinson’s,
carries the same genetic mutation.
“This leaves me in a rather unique position. I know early in
my life something I am substantially predisposed to. I now have the opportunity
to adjust my life to reduce those odds (e.g. there is evidence that exercise
may be protective against Parkinson's). I also have the opportunity to perform
and support research into this disease long before it may affect me. And,
regardless of my own health it can help my family members as well as others,”
wrote Sergey Brin on his blog.
Parkinson’s disease is a brain disorder, which occurs when
certain nerve cells (neurons) in a part of the brain called the substantia
nigra die or become impaired. Normally, these cells produce a vital chemical
known as dopamine. Dopamine allows smooth, coordinated function of the body's
muscles and movement. When approximately 80% of the dopamine-producing cells
are damaged, the symptoms of Parkinson’s disease appear.
Symptoms for Parkinson’s disease include tremor (uncontrollable shaking of
hands), slowness in movement, rigidity and difficulty with balance. In the United States,
it is estimated that 60,000 new cases are diagnosed each year, joining the 1.5
million Americans who currently have Parkinson’s disease. While the condition
usually develops after the age of 65, 15% of those diagnosed are under 50.
Sergey Brin, a native of Moscow,
received a Bachelor of Science degree with honors in mathematics and computer
science from the University of Maryland at College
Park.
He is currently on leave from the Ph.D. program in computer
science at Stanford
University, where he
received his master's degree.
It was at Stanford where Sergey Brin met Larry Page and
worked on the project that became Google. Together they founded Google Inc. in
1998, and Brin continues to share responsibility for day-to-day operations with
Larry Page and Eric Schmidt.