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Scientists have developed a promising
method that could one day replace heart surgery with cell injections
that would help reconstruct a damaged blood supply system and restore
the normal oxygen flow to the heart.
The secret lies in an experimental
implant of progenitor cells taken from human adult blood systems,
which later developed into fully functional blood vessels in mice.
The premiere was reported in Circulation Research: Journal of the
American Heart Association.
By combining two types of progenitor
cells, derived either from adult blood and adult bone marrow, or
umbilical cord and adult bone marrow, scientists managed to grow
healthy blood vessels, although for now at a slow pace.
Progenitor cells are similar with stem
cells, but differentiate through their capability of only turning
into certain types of cells. Scientists preferred the use of
progenitor cells instead of stem cells because of the high
controversy surrounding the latter.
If the experiment could prove efficient
for humans treatment, it would not only dismiss any ethical concerns
regarding the use of stem cells for any type of treatment, but it
would create a solution for ischemia, wound healing and acute
injuries, as Joyce Bischoff, lead author of the study and associate
professor at Harvard Medical School, explained.
The problem that still remains is the
slow process of recreating the blood vessels. The experiment took
seven days to complete, but scientists want to reduce that time to
one or two days, especially considering the delicate nature of heart
conditions and the necessity to act rapidly.
"What's really significant about
our study is that we are using human cells that can be obtained from
blood or bone marrow rather than removing and using fully developed
blood vessels," Bischoff said.
A faster process would most certainly
give hope for future cardiac procedures without any surgical
intervention, and the variety of progenitor cells able to recreate
the heart blood vessels easies up the process of finding a compatible
donor.
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