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For the
first time, a team of scientists managed to decode all the genes of a person
who suffered from cancer, having also been able to discover several mutations
that might have caused the fatal disease to develop.
The study
was conducted at Washington University
in St. Louis, while the results
published Thursday in the journal Nature.
Researchers used cells that had been donated by a woman in
her 50s who died of leukemia, the team having compared the affected by cancer cells’ DNA
with the one from hear healthy skin cells in order to map the genome.
They found ten mutation in the cancerous cells, which
rendered them incapable of responding well to chemotherapy, by virtue of an abnormal
growth they were unable to fight off.
The mutations have been reported to had developed later in
the patient’s life, thus scientists stated the proneness to cancer had not been
inborn.
This recent project marks the first time a person’s entire
DNA has been sequenced and also opens the door to further research concentrating on
other types of cancer than leukemia, which is expected to be performed in the
near future.
Richard K. Wilson, director of Washington University’s
Genome Sequencing Center and lead author of the study, has stated he hoped that in twenty years or less, scientists would be able to come to perform DNA
sequencing by using only a drop of blood that was to be analyzed by a computer,
which was afterwards to determine the drugs that would be most effective for
each cancer patient.
Currently, there are only a few drugs that can treat cancer,
such as Herceptin, given to women suffering from a certain type of breast
cancer and Gleevec, used for a type of leukemia and a rare gastrointestinal
cancer.
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