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In a scientific premiere, Leiden
University Medical Center (LUMC) geneticists managed to determine the DNA sequence
of a woman, identified as Dr. Marjolein Kriek, geneticist at LUMC. The in-depth
analysis and the sequence will be made public at a later date.
The sequencing took six months
to complete, and it was done with the help of the Illumina 1G equipment at the
Leiden Genome Technology Center, belonging to Leiden University Medical Center
and the Center for Medical Systems Biology.
A DNA sequence is in fact the
structure of a DNA molecule, capable of retaining information, represented as a
succession of letters, each derived from the four nucleotide subunits in the
DNA. In this particular analysis, the Illumina 1G equipment read approximately
22 billion base pairs or letters.
DNA sequencing is a mean of
establishing the order of these four letters, which sometimes can be
accompanied by other letters, representing portions of DNA with still unknown
functions. The DNA sequence is the key
to the development of all organisms.
It’s more or less like a will:
it holds heritable genetic information about the development of all living
organisms.
Scientists have been working on
human DNA sequencing on four male subjects only, so it was time for a female
DNA sequencing as well. The project was valued at approximately $40.000, but it
will take even more money and time (possibly another 6 months) to finish the
in-depth analysis.
In 2001, scientists managed to
publish the DNA sequence of four males, one of which was Jim Watson, who was
discovered to have a double helix structure. So far, there have been no
reactions from the scientific community on the latest study of DNA sequencing,
but reactions are to be expected as more details will be made public.
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