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The positron
emission tomography (PET) scanning turned out to be a useful way of diagnosing
the early stages of Alzheimer’s disease. It allows doctors to see whether a
person has "plaques" in the brain that are an indication of the
disease. These so called “plaques” are made of beta-amyloid and other
compounds.
Ville Leinonen, M.D., Ph.D., of the University of Kuopio,
Finland is the one who conducted the study. He and his team studied ten
patients who apparently didn’t suffer from severe dementia and had undergone a
biopsy of their frontal cortex because of a suspected abnormal increase of
cerebrospinal fluid in the brain. The subjects of the study were injected with
a marker known as carbon 11–labeled Pittsburgh Compound B ([11C]PiB) and then
underwent a 90-minute PET scan. The conclusion they reached was that patients
who had beta-amyloid plaques in their brain biopsy specimen displayed a higher
uptake of [11C]PiB in certain brain areas as compared with those who did not
have such accumulations.
Until now doctors could not be sure if their patients were
suffering from Alzheimer's until the brain was examined after death in an
autopsy.
The study was published online this week in the journal Archives
of Neurology and will probably be included in this October’s printed issue
as well.
26 million people have Alzheimer's at the moment. This study
shows PET scans may become a useful tool to diagnose Alzheimer's disease, a
fatal and incurable mind-robbing ailment that is the most common form of
dementia in the elderly, Leinonen explained.
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