New Study Shows MRSA Tricks Immune System
By Alice Turner
21:37, November 12th 2007
100 votes
Vote this story
New Study Shows MRSA Tricks Immune System

A new study shows that Methicillin-resistant Staphylococcus aureus (MRSA) may trick and destroy immune system cells when they are vulnerable. The research, published in the journal Nature Medicine, found that some strains on MRSA secrete a compound called phenol-soluble modulin (PSM). This substance attracts immune system cells called neutrophils and then destroys them in a process called lysis.

"This elegant work helps reveal the complex strategy that S. aureus has developed to evade our normal immune defenses," Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said in a statement.

"Understanding what makes the infections caused by these new strains so severe and developing new drugs to treat them are urgent public health priorities."

There are two main types of MRSA. The hospital-acquired MRSA, which is responsible for nosocomial infections, is much more dangerous because it is resistant to most antibiotics. The community-acquired MRSA usually is caused in the United States by a strain designated ST8:USA300. This type of infection is more virulent but a lot easier to treat, and in many cases antibiotics are not required.

"Here we describe a class of secreted staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection," the researchers wrote.

Paranoia was unleashed after this October researchers reported that MRSA was responsible for 94,000 hospitalizations and may have contributed to 19,000 deaths in 2005 in the United States. These figures were distorted by the media and interpreted as if the 19,000 deaths were caused by the MRSA, which is false. MRSA was found in 19,000 people who died, but the vast majority of those had other primary, lethal diseases.

There are antibiotics which kill of most nosocomial MRSA infections, but they are used only as a last resort as otherwise resistant strains would pop up everywhere. In fact, a MRSA dubbed vancomycin intermediate-resistant Staphylococcus aureus (VISA) has appeared, which is resistant to the powerful vancomycin antibiotic. In 2006, Merck reported in Nature that they discovered an entirely new type of antibiotic, called platensimycin, which is allegedly very successful against MRSA.



© 2007 - 2008 - eFluxMedia
dotclear

Other News in

Genetic Code Of Malaria Parasite Deciphered

Genetic Code Of Malaria Parasite Deciphered

About 40 researchers sequenced the genetic code of Plasmodium vivax, one of four malaria parasites responsible for nearly 40% of the approximate half a billion annual malaria infections that occur...

Research Institutions Collaborate On Genomic Research Project

Jim Doyle announced Friday that Wisconsin’s four academic research institutions will join forces on an initiative focused on making the state a leader in individualized medicine, a science that...

FDA Supports New Limit On Cold And Cough Medicines

FDA Supports New Limit On Cold And Cough Medicines

The Food and Drug Administration told healthcare providers and customers that it agrees with the decision the drug industry took regarding the warning labels for over-the-counter cough and cold...

QVC's Shoe Sales to Help Breast Cancer Research

QVC's Shoe Sales to Help Breast Cancer Research

With October being the Breast Cancer Awareness Month, many are trying to find ways to help raise money for further research into prevention and treatment methods for the deadly disease. In...

Advocacy Group Sues Oklahoma's Law Against Abortion

An Oklahoma law that prohibits a woman from getting an abortion before she undergoes an ultrasound and the doctors describes what her fetus looks like is being sued by the Center for Reproductive...

dotclear
Latest videos in Health
The White House Turns Pink
Teens 'chat' With Scientists...
NY Nursing Home Workers...
Toxic milk alert hits South...
Tainted Milk Scandal Spreads...

dotclear
Health You are here: Health
» Science   » Health   
E-mail To A Friend Print RSS Text size: Decrease font size Increase font size
dotclear
dotclear
dotclear
Most Popular in Health
Update: New Arms For 54-Year-Old German AmputeeUpdate: New Arms For 54-Year-Old German Amputee

» read full story
dotclear

Interested In This Topic?

News Alert will keep you informed. Find out more.
dotclear
Photos Gallery
dotclear
Today's Latest News
A Lot of Sunshine, Beauty and Happiness in "Happy-Go-Lucky”A Lot of Sunshine, Beauty and Happiness in "Happy-Go-Lucky”

» read full story
dotclear