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Teva Pharmaceutical Industries Ltd. from Israel
and Lundbeck from Denmark introduced Azilect, also
called rasagiline, which was already approved to be used in treating symptoms
of Parkinson's. Results of the phase III ADAGIO trial were presented by
Teva Tuesday during the 12th Congress of European Federation of Neurological
Societies (EFNS) in Madrid,
Spain. Thus
there is new hope for the ones suffering from Parkinson’s disease.
The newly available medication slows down the progression of
the horrible brain disorder characterized by shakes, memory loss,
hallucinations and stiffening of muscles. It usually affects people over the
age of 60 and there are four million people worldwide who suffer from this
condition.
Professor Olivier Rascol, M.D., Ph.D., Department of
Clinical Pharmacology, University Hospital, Toulouse,
France, one of
two principal investigators of the trial, was the one who unveiled the
discovery.
The ADAGIO study was made on 1,176 patients with very early
Parkinson's disease in 14 countries and 129 medical centers. Not all of them
received the drug, however. Some of them received 1 or 2 mg per day for 72
weeks, while others had a delayed treatment with 36 weeks placebo followed by
36 weeks rasagiline 1 or 2 mg once daily.
The study concluded that there were significant improvements
for the ones who started treatment right away compared to those who initiated
therapy nine months later.
"Delaying disease progression is the most important
unmet need in the management of Parkinson's disease," stated Prof. C.
Warren Olanow, professor and chairman of the Department of Neurology at the
Mount Sinai School of Medicine, New York, NY, and ADAGIO co-principal
investigator.
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