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The search for the best source of stem
cells continues, with many scientists supporting the field of stem cell
research. The most recent discovery in this domain is that made by a team of
European scientists who have developed a culture method for establishing “human
adult germline stem cells” from testicular biopsies.
For the new study conducted by Thomas
Skutella and colleagues at the University
of Tubingen, the
researchers biopsied the cells from human testicles and grew them in laboratory
cultures. They used testicular tissue from 22 men, aged from 17 to 81, to
create what they called “germline stem cells.” Researchers found that after a
few weeks of growth in laboratory cultures containing factors that supported
the development of stem cells, the testes cells took on the characteristics of
embryonic stem cells.
According to the study published in Thursday’s
issue of the journal Nature, the new type of stem cells could be useful for growing
bone, muscle, neural and other kinds of cells that might be used to replace or
repair the damaged tissue in male patients with generative diseases. (The
benefits of this new method would probably apply only in men.)
“We have developed a culture method for
establishing human adult germline stem cells from testicular biopsies,”
Skutella and colleagues wrote. “These cells changed their properties, losing
characteristics of spermatogonial cells and acquiring characteristics ...
similar to those of human embryonic stem cells.”
The discovery allows researchers the
opportunity to study diseases like Parkinson or any kind of inherited disease
using biopsies taking from people with these conditions. Researchers say the
same technique can be used to study many other genetic diseases. The stem cells
might be used to create new cells that could replace the diseased ones in
patients who suffer from genetic diseases.
Stem cells have the potential to develop
into many different cell types in the body, serving as a sort of repair system
for the body. They can divide without limit to replace other cells in the body
as long as the person or the animal is still alive. Unlike other cells such as
muscle cells, blood cells, or nerve cells, the stem cells divide and each new
cell may remain a stem cell or become another type of cell with a specialized
function.
Another method developed during the last
two years uses skin cells taken from patients, reprogramming them into
embryonic-like stem-cells. The technique uses genes and viruses, but
researchers have tried to improve this method by developing a safer way of
obtaining stem cells from common skin cells without using harmful viruses that
can cause cancer. They found a new method that uses adenoviruses. The
adenovirus doesn’t integrate into the genome, so the cells aren’t altered
genetically.
But the technique which uses testicular
biopsies is easier and it uses a man’s own cells to heal his body. This means
that the method could be used without fear that the body would reject the
cells. Another advantage of this method, compared to embryonic stem cells is
that it has fewer moral restrictions and problems and the testicular cells are
natural.
Both the technique that reprograms ordinary
body cells into stem cells and the method using testicular cells avoid embryos,
but scientists say this advantage is not a reason strong enough to give up on
research on embryonic stem cell research.
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