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Novavax Inc. announced on Tuesday that their new bird flu
vaccine that uses a mock version of the virus is actually safe for further use.
Novavax's VLP candidate is directed against the H5N1 A/Indonesia/05/2005 avian
influenza strain that emerged in humans in Indonesia in 2005 and has caused
135 human cases, 81% of which were fatal.
The vaccine was said not to contain an adjuvant however it
induced hefty neutralizing antibody responses.
The study evaluated individuals who received two injections
of 15 micrograms (mcg), 45 mcg, 90 mcg or placebo. All subjects tested negative
for neutralizing antibodies to the H5N1 A/Indonesia strain before vaccination
and no responses were observed among individuals who received a placebo. The
best response was received on behalf of patients getting the highest dose.
Novavax is developing avian flu vaccines using its
technology with GE Healthcare, a division of General Electric.
They are also working on a project that will eventually lead
to a rapid and cheap deployment in outbreak areas where a vaccine could be
developed in about three months’ time especially for a certain local outbreak.
Thus potentially human disasters will be avoided.
Novavax President and Chief Executive Officer Dr. Rahul
Singhvi explained: "These results are strong and very competitive and they
compare well with any vaccine against pandemic flu, whether licensed or in
development."
The Novavax vaccine is concentrated around hree proteins
found in flu viruses: the neuraminidase (N), the M1
protein, and hemagglutinin, the one common vaccines battle against most of the time.
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