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Professor Ian Wilmut, the Scottish scientists who led the
team that created Dolly the sheep ten years ago, decided to embrace a new
technology for a non-embryo cell production.
In 1997 Wilmut developed the nuclear
transfer cloning technique, which involved creating stem cells from human
embryos. The stem cells are the primal cells found in all multi-cellular
organisms, which have the potential of differentiating themselves into a
diverse range of specialized cell types.
Embryonic stem cells, derived from blastocysts, are derived
from the inner cell mass of an early stage embryo. They are capable of turning
into any type of cell type, whereas multipotent progenitor cells found in the
adult can only be coaxed into forming some tissue types.
In the lab, scientists harvest stem cells from cloned
embryos. By producing stem cells that carry the genetic defects of diseases,
researchers believe they will be able to understand the complex mechanisms
behind incurable human diseases, potentially leading to new cures.
According to BBC, Ian Wilmut decided not to pursue a license
to clone human embryos following new research by a Japanese team into coaxing
stem cells from the skin cells of mice. The study lead by Professor Shinya
Yamanaka of Kyoto
University is due
to be published in a scientific journal on Tuesday.
"The work which was described from Japan of using a
technique to change cells from a patient directly into stem cells without
making an embryo has got so much more potential.” Wilmut said for BBC.
"Even though it's only been described for the mouse,
when we were considering which option to pursue, whether to clone or whether to
copy the work in Japan, we decided to copy the work in Japan.", he added.
Last year in August Professor Shinya Yamanaka and his colleagues reported
that hey have been able to make adult cells act like embryonic stem cells, at
least in mice.
Yamanaka and his colleagues found 24 genes that are
expressed in early embryos. They found that a combination of four of these
cells could make adult cells "pluripotent."
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