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Harvard scientists have produced a library
of stem cells based on ordinary skin and bone marrow cells from patients, which
allow researchers to study the cells that degenerate in patients who suffer
from degenerative diseases and from many more diseases without ethical restrictions.
The new cells, called induced pluripotent
stem cells, also known as iPS cells, are made using a new technique which reprograms
cells, giving them all the qualities of embryonic stem cells, such as the
potential to develop into many different cell types in the body, serving as a
sort of repair system for the body. They can divide without limit to replace
other cells in the body as long as the person or the animal is still alive.
Doug Melton, a co-director of the Harvard
Stem Cell Institute said the new disease specific cell lines “represent a
collection of degenerative diseases for which there are no good treatments and,
more importantly, no good animal models for the most part in studying them,”
according to the Associated Press.
A new laboratory has been created to serve
as a repository for the cells, and to distribute them to other scientists
researching the diseases, Melton said, according to the same source.
The new discovery allows researchers to
study the disease in progress in a Petri dish. By comparing diseased cells to
healthy cells in a Petri dish, scientists hope to understand what causes the
disease and to test new drugs.
Last week, scientists at Harvard and Columbia universities
announced that they created the first stem cell lines from skin samples
provided by ALS patients. Researchers used a cellular programming recipe first
developed by Shinya Yamanaka, a researcher at Kyoto
University in Japan. The
technique “opens doors to making patient-specific stem cell lines,” said Dr.
Kevin Eggan, principle faculty member at the Harvard Stem Cell Institute and
lead author of the study.
The finding supports the theory that almost
any cell in the body can function as a stem cell and is capable of being
reprogrammed into many different cells in the body.
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