How would you react if you found out there are high chances
that you develop a certain condition at some point in your life? Google
co-founder Sergey Brin is in that position, and decided to share his experience
with the public on this Too blog.
Brin’s wife, Anne Wojcicki, who is co-founder of a personal
genomics and biotechnology company that is working on new ways of helping
people become aware of their genetic information and what may result from that,
first introduced Brin to genetic testing.
At first, 23andMe genetic testing started off with a certain
dose of skepticism for Brin, but as he began assembling pieces of his DNA
puzzle, he also became quite excited about the prospects of finding out his
genetic risk for most diseases.
At his wife’s suggestion, Brin looked into his genetic data
for the G20195 mutation, to find out whether he might pose a risk to Parkinson’s
disease. His mother suffered from this condition, and so did his mother’s aunt,
which raised a few questions about such a possibility for him, although a
hereditary inheritance of the disease has never been established.
To his surprise, he found out that both him and his mother
carry the G20195 mutation. This leaves him with a 20 to 80 percent chance of
developing Parkinson’s in his lifetime, much higher than an average person.
According to Brin, this puts him in a rather unique
position: “I know early in my life something I am substantially predisposed to.
I now have the opportunity to adjust my life to reduce those odds […] I also
have the opportunity to perform and support research into this disease long
before it may affect me. And, regardless of my own health it can help my family
members as well as others.”
Parkinson’s disease or PD is a disorder affecting over 1
million Americans, 40% of which are under the age of 60. There are a lot of
unanswered questions about the cause of the disease, or the cure. What scientists
do know is that it starts from the degeneration of nerve cells in the
mid-brain, and that as it progresses, it may ultimately become debilitating.
As the affected nerve cells in the brain stop producing the
necessary amount of neurotransmitting chemical dopamine necessary for coordinated
movement and muscle relaxation, the disease starts interfering with body
movement, but some patients may develop depression and dementia.
Parkinson’s disease knows no sex or ethnic boundaries: “Parkinson’s
does not discriminate. It afflicts people regardless of gender, race,
background, behavior, lifestyle or geographic area. Despite the common
perception that PD is the “old person’s” disease, the average age of diagnosis
is 57 years, with many diagnosed in their 30’s and even 20’s” – Northwest Parkinson’s
Foundation.
According to the World Health Organization, 100-180 people
per 100,000 of the population are affected by Parkinson’s. Who also notes that
there is a rising prevalence with age and a higher prevalence and incidence of
PD in males.
Brin ended his blog with a positive statement, saying he
feels fortunate to be in this position. “Until the fountain of youth is
discovered, all of us will have some conditions in our old age only we don’t
know what they will be. I have a better guess than almost anyone else for what
ills may be mine – and I have decades to prepare for it.”