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GlaxoSmithKline PLC announced Friday that it would halt
development of its malaria drug Dacart and would stop selling another drug
Lapdap because both appear to lead to anemia.
Malaria is spread by mosquitos and it generally appears in
tropical and subtropical regions, including parts of Asia, and Africa. Malaria kills more than one million people each
year, mostly in the developing world, according to the World Health Organization.
According to tests conducted by GSK and its Partner
Medicines for Malaria Venture, both drugs lowered hemoglobin concentration in
patients with hereditary enzyme deficiency disorders, which affects 10 to 25
percent of the sub-Saharan population in Africa.
A deficiency of hemoglobin can lead to anemia, which reduces the amount of
oxygen available to the body and causes fatigue.
The tests showed that patients taking Dacart experienced a
bigger drop in hemoglobin levels that those taking Novartis AG’s Coartem, GSK
said in a statement according to the Wall Street Journal. Dacart combines
Lapdap with a form of artemisinin, a natural substance derived from a Chinese
plant.
Also, patients taking Lapdap had the same results as patients
taking Dacart, which prompted GSK to recall it from pharmacies in Kenya, the only
country where it is sold, the company added.
GSK’s announcement reduces the number of available malaria treatments on the
market. Health experts encourage companies to put as many drugs on the market
as possible in an effort to increase competition and reduce prices.
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