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Couch potatoes all over the world, here’s your chance to
lose weight due to a “magic” pill, which allows you to eat as much as you like
without putting on a pound. Too much to be true, you might add, but French researchers
say the experimental drug SRT1720 can essentially trick the body into believing
food is scarce even when it is not. It’s true that the drug was only tested on
mice but further tests on humans might turn your dream into the most desired
reality.
The drug, SRT1720, a chemical cousin of red wine extract resveratrol,
targets protein SIRT1, which is believed to combat ageing and help prevent
heart disease and cancer. The drug was developed by Sirtris Pharmaceuticals, a
GlaxoSmithKline company.
The University
of Louis Pasteur
researchers found that giving mice a low dose of SRT1720 for 10 weeks partially
protected them from gaining weight on a high-fat diet. On the other hand,
higher doses completely prevented weight gain. The drug appeared to improve
blood sugar tolerance and insulin sensitivity, which are important for warding
off diabetes. Moreover, it gave the mice greater athletic ability.
“These
results show that new synthetic SIRT1 activators can reproduce the positive
metabolic effects that were previously demonstrated using resveratrol. But
unlike resveratrol, these new chemical entities target only the SIRT1 pathway,
making them more selective and potent for achieving these metabolic benefits,” Researcher
Professor Johan Auwerx, of the Ecole Polytechnique Federale de Lausanne in Switzerland,
said.
The mice on the experiment showed no side effects, but scientists said it’s
too early to use the drug in humans. More tests are needed to test its safety
and efficacy before it could be used in humans.
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