Prostate-cancer screening or the PSA test for men aged 75 or
older should be stopped because there is more evidence of harm than benefit,
according to a US
advisory panel.
On Monday, the Preventive Services Task Force released a
statement in which it updated its 2002 report by saying that more evidence is
needed to determine if men under 75 could benefit from screening.
“Most prostate cancer grows very slowly, and many men with
prostate cancer die of something else before the prostate cancer causes a
problem. Early detection, however, puts men at risk for unnecessary worry and
side effects of treatments,” such as impotence, incontinence and bowel
problems, the task force said.
The PSA test measures a protein in the blood produced by
prostate tissue. The test generally indicates the presence of a tumor but
confirming it requires a biopsy. The measure has significantly increased the
number of prostate cancer cases being diagnosed at very early stages, but there
is no evidence to prove whether it translates into a reduction in death rate
from the disease.
The 2002 report concluded there was insufficient evidence to
recommend prostate screening for men of all ages.
Officials at several leading medical groups, including the
National Cancer Institute and the American Cancer Society, praised the new
guidelines. However, there were others criticizing them. Fore example, William
J. Catalona, a professor of urology at Northwestern University
thinks, “they’re really missing the boat. It’s a disservice to patients. A lot
of men die from prostate cancer, and there’s just an overwhelming amount of
evidence that screening saves lives,” he said.
Prostate cancer is diagnosed in approximately 220,000 US men
annually and about 28,000 die of it, which makes it the most common cancer and
second-leading cancer killer among men.
The new guidelines are supporting the findings of a study
published early last month in the Journal of the American Medical Association,
according to which widely used hormone-blocking drugs do not improve survival
in older men with early prostate cancer that has not spread.
The hormonal drugs are used to suppress the testosterone
that feeds prostate cancers and are usually given to the elderly although there
is no scientific evidence that they really help. On the other hand, they have
as most obvious side effect sexual dysfunction, but the therapy has been
recently linked to greater risks such as diabetes, bone fractures, heart
disease, reduced muscle mass, weight gain, hot flashes and decrease in mental
acuity.
The study, conducted by researchers at the University of
Medicine & Dentistry of New
Jersey, analyzed thousands of medical records of men
with a median age of 77 diagnosed with early prostate: 40 percent of which had
received hormone therapy for an average of 18 month while the rest opted for
watchful waiting.
The analysis found that nearly 20 percent of those on
hormone therapy died of prostate cancer within 10 years compared with only 17.4
percent of those in the other group.
“Use of hormone therapy does not improve survival. The
reason patients want this is they want something that will improve their
quality of life or their survival. But hormone therapy has a detrimental effect
on quality of life. And we cannot find any survival benefit for these men in
their 70s with very early-stage cancer,” Dr. Grace Lu-Yao, lead author of the
study, said at the time.
Given these findings, the task force recommended “larger,
longer-term studies” to determine whether such measures benefit the old men.
Also, the panel recommends that men “make a decision based on their individual
risk factors and personal preference,” Dr. Ned Calonge, chief medical officer
of the Colorado Department of Public Health and Environment and chairman of the
task force, said.
The new recommendations can be found in this month’s Annals
of Internal Medicine.