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One day the ancient creatures
could be brought to life again through a move that has nothing to do with a
fantastic story, such as the one from Ben Stiller’s comedy “Night at the
Museum”. A team of scientists have started to decode the DNA of ten woolly
mammoths from a wide swathe of northern Siberia
and with dates of death spanning approximately 38,000 years - from 50,000 years
to 12,000 years ago. They have used a technique that is likely to revolutionize
the genetic testing of the extinct creatures.
The researchers, Stephan C.
Schuster and Webb Miller of Penn State University,
working with Thomas Gilbert from Copenhagen,
have been lucky enough to discover a new source of genetic material for
studying the DNA of the ancient huge creatures; they have used samples of hair and
they have reconstructed the complete mitochondrial genomes of the animals. The
scientists have been able to such great results because hair proved to be a
better source of DNA than muscles or bones, for example. Mammoths have lived
about 50,000 years ago and it would have been difficult for the scientists to
study their putrefied bones or muscles. When the animals died thousands of
years ago their bodies putrefied and the bacteria got throughout them; the
bacterial DNA made up 50 to 90 percent of the raw DNA extracted from the
remains of the animals. So, when the researchers have found mammoth hair for
their study, they have been able to get to revolutionary findings.
And because the DNA sequences are
reportedly very detailed, the new study is expected to cast a new light on why
these animals became extinct.
"When people thought of
sequencing DNA from hair, the usual assumption was that the material must come
from the hair root, which contains recognizable cells, because the hair shaft
appears to be dead," Miller explained, "however, we now know that a
hair shaft consists essentially of DNA encased in a kind of biological
plastic." Protected in this way, the DNA resists damage, and readily can
be separated from any bacteria that may contaminate the sample. "We
discovered, moreover, that the DNA in hair shafts is remarkably enriched for
mitochondrial DNA, the special type of DNA frequently used to measure the
genetic diversity of a population," Gilbert added.
The new route to the genetic
material of extinct animals also will enable researchers to study the
relatedness of individual animals from different populations at a much higher
resolution than previously thought possible. "We plan to use hair and
other keratin-containing body parts, such as nail and horn, to untangle the
secrets of populations that lived long ago, so these populations can send a
message from the past about what it might have taken for them to survive,"
Schuster said. "This discovery is good news for anyone interested in
learning more about how species of large mammals can go extinct."
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