New research published in this week’s New England Journal of
Medicine reveals that noninvasive CT scans are nearly as accurate at imaging
coronary artery blockages as conventional angiography and are much safer for
many patients.
An angiography requires inserting a slim catheter tube into an
artery in the groin and running it up into the arteries near the heart. The
procedure usually takes 30 to 45 minutes plus another hour of recovery;
complications, though rare, include heart attack and stroke.
Researchers at Johns Hopkins University in Baltimore
discovered that the new expensive CT scans can detect narrowed blood vessels in
people with suspected heart disease nearly as well as the conventional
angiogram. More exactly, they found that so-called 64-row computed tomography,
or CT scans were 93 percent as precise as conventional cardiac catheterization
without subjecting a patient to an invasive procedure. The only downside is
that the patients are exposed to relatively high levels of radiation. A 2007
study linked up to 2 percent of all US cancers to CT radiation.
For the study, Dr. Julie Miller, an interventional
cardiologist at Johns Hopkins University School of Medicine in Baltimore
and colleagues at nine hospitals in the United
States, Canada,
Germany, Japan, Brazil,
Singapore and the Netherlands
identified 291 patients with symptoms of coronary artery disease who were
candidates for traditional angiograms. Their median age was 59, and 74 percent
of them were men.
The researchers used a 64-slice CT scanner made by Toshiba
Medical Systems, which funded the study along with the National Institutes of Health
and private foundations. Then the participants underwent conventional
angiograms.
In 163 patients with the highest degree of coronary artery
disease, the CT angiograms were 93 percent as good as the traditional
angiograms, the study showed. Overall, the CT scans accurately identified 85
percent of the patients who had the biggest blockages and 90 percent of the
patients who did not.
Also, the researchers found that 91 percent of patients who
were identified by the CT scans as having the most severe disease were
correctly diagnosed, as were 83 percent of patients whose scans did not reveal
large blockages.
Although some argue that the new CT scans might not be as
good as angiograms, “our study shows they do have value, because they have a
high degree of diagnostic accuracy to identify patients with tight heart
blockages. Having the scan is a noninvasive procedure, and that is very
attractive. Patients do not undergo the risk, even though it is small, of
angiography,” Dr. Miller said.
However, the study concluded that scanners “cannot replace
conventional coronary angiography at present.”
According to the American Heart
Association, more than 1.2 million patients in the US undergo cardiac angiograms each
year and 1 percent to 2 percent of those cases result in complications. The National Center for Health Statistics at the
Centers for Disease Control and Prevention estimates that 25 people die every
year as a result of the procedure.