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The latest clinical trials have
shown that Genentech’s cancer drug, Avastin, proved its effectiveness in
slowing the progression of breast cancer tumors when combined with chemotherapy
treatment. The drug has already been approved in colon and lung cancer
treatment, and Genentech is expecting a green light in breast cancer treatment
as well.
The company publicly announced
the results of the study, saying Avastin managed to lengthen the time before
the cancer spreads, and is now waiting for the Food and Drug Administration to
make a decision on February 23. An approval of the cancer drug would mean a significant
boost in sales for Genentech, a company whose U.S. sales of Avastin alone reached
$2.3 billion in 2007.
Previous discussions in December
on whether to approve or reject the use of the cancer drug for treatment of
breast cancer reached no agreement, as the FDA advisory panel considered there
were no sufficient data from earlier studies to allow an equitable analysis
risks-benefits regarding Avastin. The latest study released could be exactly
what Genentech could need to swing the balance in its favor.
“We are pleased that a second
Phase III study in this population of breast cancer patients showed a
significant improvement in progression-free survival,” said Hal Barron, chief
medical officer of Genentech, in a statement. “The trial also demonstrated
Avastin’s potential with a different chemotherapy in this disease,” Barron
added.
So far, the FDA commission analyzing
another study said the drug’s toxic side effects outweighed the beneficial
effects and at the same time, the fact that it was hard to establish the moment
the cancer would start to worsen could also stand in the way of a favorable
decision on February 23.
Approximately 170,000 women have
been diagnosed with breast cancer in 2007 in the United States, and at least
one in 8 women are affected by it during their lives. In the Unites States,
breast cancer is responsible for more deaths than any other form of cancer,
except lung cancer, with 40,000 deaths last year alone.
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