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Another promising step towards finding a cure for
diabetes type 1 and type 2 has been made. Scientists have succeeded in
transforming one type of cell into another meaning they turned ordinary
pancreas cells into potential insulin sources. The newly
created cells made insulin in diabetic mice, though the mices were not actually
cured.
Scientists at the Stanford University School of Medicine are
the ones responsible for the discovery. "Everybody's been wondering what
process initiates type-1 diabetes," said Hugh McDevitt, MD, professor of
microbiology and immunology and the study's senior author.
Now they’ve unveiled
the mystery. It appears that the immune signal interferon-alpha is an early
cause in a chain of events that sets sugar metabolism and makes patients
dependent on insulin injections for the rest of their lives.
The researchers succeeded in using three genes of an
ordinary virus in order to transform mouse exocrine cells, which make up about
95 percent of the pancreas, into the insulin-producing beta cells that are
destroyed in type 1 (juvenile diabetes).
But before experiments begin in people, Dr. Douglas Melton a
Howard Hughes Medical Institute researcher explained they want to find a way to
transform cells without using a virus. Using viruses to treat people, he noted,
is risky and disagrees with rules and principles approved by Food and Drug
Administration experts.
The news was published today by the journal Nature and it
also brought into discussion the possibility of also treating heart disease,
strokes and many other medical problems that involve cell reprogramming by
using this method.
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